Lamellar Ichthyosis/non-Bullous Ichthyosiform Erythroderma - Key Clinical Features

Skin abnormalities

• collodion membranes or ichthyosiform erythroderma at birth
• generalized lichenification
• dark brown (LI-type) or fine white (NCIE-type) generalized scaling
• erythroderma ranging from very mild to severe
• sometimes diffuse palmoplantar keratoderma

Others

• ectropion
• often severe heat intolerance due to the reduced or absent ability to sweat
• alopecia (in severe hyperkeratotic conditions of the scalp)