Harlequin Type Ichthyosis Congenita - Key Clinical Features

Skin abnormalities

• Ichthyosis
• Dense "armor"like scales
• Large yellowish plaques
• Deep skin fissures
• Swollen fingers and toes

Others

• Ectropion
• Eclabium
• Flattened nose
• Ear anomaly (shape/structure)
• Stillbirth/neonatal death