Congenital Reticular Ichthyosiform Erythroderma - Diagnostic Tests

Diagnostic Tests

Congenital Reticular Ichthyosiform Erythoderma - Histologic findings

Reduced Keratin 10 levels in affected skin. Band-like parakeratosis. Psoriasiform acanthosis. Vacuolization of the keratinocytes with binuclear cells in the upper epidermis. Deposition of amyloid in the dermis. Mislocalization of mutant KRT10 to the nucleolus can be determined by co-staining with fibrillarin.

Congenital Reticular Ichthyosiform Erythoderma - Molecular genetic testing

DNA sequencing of the KRT10 gene.

Molecular Genetic Tools


Mutation Database